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To maintain good pump performance, the system must be clean, solvent and reagent quality guaranteed, and the mobile phase filtered and degassed. Here are a few precautions to prevent pump failure: 1. High quality reagents and HPLC grade Solvent; 2, filter the mobile phase and solvent; 3, degassing; 4, venting exhaust air every day when the start of use, washing away the buffer solution from the pump after the work; 5, do not let water or corrosive solvents remain in the pump; , Regular replacement of gaskets; 7, when necessary, add lubricants; 8, consult the pump operation manual for other suggestions. Pumps in good working order should be able to stabilize the baseline on the chromatogram; reproducibility of retention time is good. Fluctuations in isocratic elution are less than 2%. Gradient elution pressure changes should be slow and steady. In order to rule out the failure as soon as possible after the failure, usually should be standing seal, check valve (inlet and outlet), pump head device, all kinds of fittings, fuses and other components, and replacement tools.